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Job Summary:

Novosteo was founded to reduce the morbidity, mortality, and loss of productivity associated with bone fractures.  Based on discoveries of agents that accelerate bone regeneration and breakthroughs in methods to target these agents selectively to fracture surfaces, Novosteo has designed a series of fracture-targeted drugs that concentrate a drug's healing power specifically at the fracture site, thereby greatly accelerating and improving the healing process. The mission of Novosteo is to reduce the debilitating and often life-threatening effects of bone fractures. This job provides the exciting opportunity to be part of an innovative team contributing to the development and discovery of new pharmacological solutions for life threatening orthopedic diseases.

Responsibilities and Duties:

• Design perform and evaluate appropriate cellular and animal studies to evaluate efficacy of bone related drugs
• Perform in vivo preclinical animal models
• Perform In vitro assays to evaluate drugs performance
• Asses the performance of drugs via microCT evaluation and histomorphormetic calculations
• Surgically create different orthopedic diseases
• Perform histomorphometric analysis of bone
• Perform Immunohistochemistry evaluation of tissue sections
• Prepare tissue for histology, and stain with bone appropriate stains
• Perform Biomechanical evaluation of biological tissue
• Maintain and manage bacterial and eukaryotic cell cultures
• Maintain and manage imaging, and biomechanical instruments
• Perform, optimize, and evaluate the results from biological activity assays
• Evaluate toxicities generated by drug treatment in serum and tissue samples
• Prepare and evaluate histological samples
• Contribute towards large experiments and projects
• Write study reports
• Manage and direct the work of interns, research associates and technicians

Qualifications and Skills:

• PhD in bone biology, molecular biology, biochemistry, bioengineering, or microbiology or related field
• 5 years lab experience
• Experience running animal experiments
• Experience with micoCT, biomechanics and bone pathologies
• Experience with ELISAs, qPCR, and other enzymatic assays
• Experience with cell culture
• Experience with in vivo imaging
• Experience with microCT imaging
• Analytical skills for conducting scientific experiments and analyzing them with precision and accuracy
• Communication skills for writing and publishing research papers and reports, giving presentations and communicating with team members
• Experience with Microsoft word, excel, power point, graph pad prism, image J, and other image analysis analytical software
• Critical-thinking skills for drawing conclusions from experimental results through sound judgment and reasoning
• Interpersonal skills for working well with others on a team towards a common goal
• Perseverance to be thorough in their approach to problems and in their research
• Critical thinking skills when using analysis and scientific experiments to identify solutions to complex scientific problems
• Time-management skills for meeting deadlines when conducting research and prioritizing tasks