We are looking for a highly motivated individual with strong background and technical expertise in cell and molecular biology and bioinformatics for our program on transcription factors in joint biology and arthritis pathogenesis. In this newly funded program we are using Omics technologies (RNA-seq, single cell-RNA-seq, ChIP-seq and epigenetic analyses) to identify regulatory gene networks and test their role using in vitro and in vivo models in mutant mouse strains. Genes that are identified to be essential regulators of homeostatic processes or to promote arthritis pathogenesis are used in drug screening assays. The laboratory has preclinical models for proof of concept validation of drug targets and drug candidates.
PhD in Biology, Bioinformatics, Genetics, Biostatistics, or related field with 0-2 years of relevant experience; or MSc in Bioinformatics, Biostatistics, Epidemiology or related field and 2+ years of relevant experience. Experience applying bioinformatics tools to next generation sequencing data.
ChIP-Seq, RNA-Seq, single cell RNAseq.
Internal Number: 566
About Scripps Research Institute
The Scripps Research Institute, one of the country's largest, private, non-profit research organizations, has always stood at the forefront of basic biomedical science, a vital segment of medical research that seeks to comprehend the most fundamental processes of life. In just three decades the Institute has established a lengthy track record of major contributions to the betterment of health and the human condition.
The Institute has become internationally recognized for its basic research into immunology, molecular and cellular biology, chemistry, neurosciences, autoimmune diseases, cardiovascular diseases, virology and synthetic vaccine development. Particularly significant is the Institute's study of the basic structure and design of biological molecules; in this arena TSRI is among a handful of the world's leading centers.