The Growth Factor Mechanobiology Lab (PI: Michael Albro) in the Boston University College of Engineering has an open position for a talented and highly motivated postdoctoral research associate with outstanding research credentials to work on an NSF-funded project in the area of growth factor mechanobiology in musculoskeletal connective tissues.
This research project builds upon an exciting growing area of mechanobiology: the role of physiologic mechanical loading on the activation of latent TGF-beta in articular cartilage. The project aims to: 1) perform novel quantitative measurements of the latent TGF-beta activation rate in response to physiologic/injurious loading regimens, 2) examine the functional role of TGF-beta activation in coordinating load-triggered repair of the cartilage matrix, and 3) examine the dissipation of this repair mechanism with age and osteoarthritis. The elucidation of this intrinsic mechanism and its limitations is likely to shed significant insights into the initiation of age and trauma-associated osteoarthritis.
In a parallel project, the postdoctoral research associate will have the opportunity to develop novel pharmacological therapeutic platforms to treat degenerative pathology. This work will utilize insights from these foundational basic-science advances in order to develop strategic, targeted molecular platforms to restore growth factor regulation and reverse growth factor-mediated pathology.
Initial appointment is for one year, renewable for a second year.
The successful applicant will have a strong publishing record in orthopaedic mechanobiology or tissue engineering. Ideal candidates should have experience and expertise in at least some of the following areas:
Microscopy techniques (confocal, second harmonic generation)
Tissue mechanical characterization techniques
Mechanical bioreactor utilization and development
To apply, please send a statement of interest, a CV, and the names of three references to Prof. Michael Albro (email@example.com).
About Albro Lab, Boston University
The Albro Lab in the Boston University College of Engineering investigates an exciting, growing area of mechanobiology: the role of mechanical and extracellular interactions on the activity of growth factors in musculoskeletal tissues. Current research avenues focus on three key areas: 1) understanding the role of mechanobiological phenomena on the development and degeneration of musculoskeletal tissues, 2) developing insight-based drug delivery platforms to halt the progression of tissue degeneration, and 3) developing tissue engineering platforms to repair degenerated musculoskeletal tissues. The lab consists of a highly multidisciplinary environment with state of the art work performed in the areas of biomechanics, biochemistry, spectroscopy, and biomaterials science.