Become a member of a research engineering team under the supervision of Principal Investigator Dr. Karina Nakayama , an Assistant Professor in the Biomedical Engineering Department. Participate in efforts to develop engineered therapies for the treatment of cardiovascular and musculoskeletal injuries and disease. Employ combinatorial approaches for controlling endothelial angiogenic phenotype and the muscle stem cell niche to fabricate engineered tissues and materials for transplantation into small animal models to achieve the goal of tissue regeneration and functional recovery.
This position will involve working on collaborative team projects composed of stem cell biologists, computational scientists, and clinician scientists.
Independently conduct in vivo small animal studies using multiple cardiovascular and musculoskeletal surgical models and imaging modalities.
Conduct experiments using molecular and cell biology techniques, including cell and tissue culture, molecular biology and protein assays, histology, fluorescence microscopy, and image processing.
The Senior Research Assistant may be exposed to blood borne pathogens, and is expected to handle animals in support of research activities.
Data Analysis and Recording Duties (20%):
Generate data and perform quantitative analysis on experimental results generated using all the above techniques/protocols for investigators use in preparation of reports and publications.
Maintain detailed records of all experimental procedures, data collection and analysis using best practices.
Give oral presentations of research findings at group meetings and assist in the write up of results for publication.
Use computer software to input and manage data for analysis.
Management and Oversight Duties (5%):
Manage the daily functions of the laboratory including monitoring and purchasing laboratory supplies, managing budgetary activities, and communicating with external personnel including vendors and severing at a point of contact for equipment and services.
Assist with lab-wide compliance with all safety regulations and create clear and detailed SOPs to support laboratory operations.
Serve as a strong individual contributor and also participate as a collaborative team member.
Bachelor's degree with major courses in field of research and 1 to 3 years of relevant experience
Advanced experience with small animal surgical models including hindlimb ischemia, volumetric muscle loss models, and tail vein injection
Advanced experience with non-invasive imaging modalities including laser doppler, microCT, and bioluminescent imaging
Strong working knowledge of muscle physiology procedures, treadmill-based and voluntary wheel running protocols, and rodent gait capture/acquisition
Working knowledge of fluorescence microscopes
Proficient with and demonstrated experience in cell and molecular biology and biochemistry techniques including cell culture, cell transfection, PCR, histology, immunofluorescence and FACS
Ability to work independently and effectively as a team with a diverse range of individuals with varying abilities and backgrounds
Motivated to learn, create, innovate and improve
Ability to multi-task and adjust/adapt to project developments
Ability to prioritize tasks and meet multiple deadlines on concurrent projects, organize and execute a variable workload
Excellent analytical and problem-solving skills
Ability to design and conduct experiments, analyze data, and communicate findings to internal and external audiences
Excellent written and oral communication and presentation skills
Demonstrated knowledge of basic computer software for data generation and record keeping such as MS Word, MS Excel, Adobe Photoshop and ImageJ
Ability to work with hazardous materials, which may include chemical and biologically hazardous materials incompliance with health and safety guidelines (Additional safety training may be required)
Experience managing laboratory supply inventory, reagent preparation, and waste disposal
Promotes a culture of safety and commitment to personal responsibility and accountability
Ability to work weekend and occasional evening hours if needed to meet project deadlines
Bachelor's or advanced degree or equivalent experience in animal science, molecular/cell biology, biochemistry. Bioengineering, or related field
2 years of experience as research assistant or equivalent
2 years of experience in surgical animal models and in vivo imaging modalities
Previous experience in lab management
Apply here online. Please be sure to upload a cover letter and Resume or CV.
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